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Endometrial Biopsy

An endometrial biopsy is a way for your doctor to take a small sample of the lining of the uterus (endometrium). The sample is looked at under a microscope by the pathologist for abnormal cells. An endometrial biopsy may be done to find the cause of abnormal uterine bleeding, to check for overgrowth of the lining (endometrial hyperplasia), or to check for cancer. It is often performed prior to a hysterectomy or uterine ablation. We use a soft device shaped like a straw (pipette) to suction a small sample of lining from the uterus. This method is fast and may cause some cramping.

How to prepare for an endometrial biopsy:

  • Tell your provider if you are or think you might be pregnant. An endometrial biopsy is not performed during pregnancy.
  • Inform your provider of all your medications and any allergies you may have.
  • We recommend you take 600-800 mg of Motrin or ibuprofen approximate 1 hour before appointment. This will help decrease the amount of cramping you experience.
  • Occasionally, we prescribe a medication called cytotec that you take the night before your procedure. It helps soften your cervix and makes it easier to perform the biopsy. We use this medication commonly if you are post-menopausal or have never had a vaginal delivery. Please ask your provider if you need this medication.